A peracetylated α-D-mannose ligand equipped with a thioacetate (SAc)-protected thiol through a hydrophilic PEG3 spacer. The thioacetate is a masked thiol that is deprotected under mild basic conditions to reveal a free thiol for maleimide or disulfide conjugation. The sugar hydroxyls are additionally acetate-protected to increase lipophilicity for cell membrane permeability. This compound provides an α-D-mannose building block for glycoconjugate synthesis and the construction of probes for mannose-recognizing receptors and lectins, including the mannose receptor (CD206) and DC-SIGN, with relevance to immune-targeting and pathogen-recognition research.