Product Portfolio

A Modern Glycoproduct Portfolio for the Omics Era

Glycomics and glycoproteomics are generating tremendous amounts of data in addition to the well-established genomics, transcriptomics, proteomics, lipidomics and metabolomics fields. Integration of the various ‘omics’ fields is moving science toward a holistic understanding of cellular biology in health and disease. Carbohydrates are at the interface of these fields.

We have developed a modern glyco product portfolio designed to help researchers explore glycobiology for glycotherapeutic applications.  We translate complex carbohydrate chemistries into unique, leading-edge products designed to help researchers explore and exploit glycobiology with a view to advancing the field and creating new biomedical applications that advance human health.

We are involved in virtually countless applications from GalNAc ligands recognized by asialo glycoprotein receptors (ASGPR) to glycopeptides for cancer immunotherapies to glycoconjugation for preclinical vaccine development.

Glycan Ligands for Targeting

Glycan ligands for targeting such as N-acetyl galactosamine (GalNAc), galactose (Gal), mannose (Man), mannose-6-phosphate (M6P), sialosides and others, play a pivotal role in the targeted delivery of therapeutics by exploiting their natural affinity for specific cell surface receptors. If you need targeted ligands for drug delivery, we bring decades of knowledge and experience in producing cell-specific carbohydrate ligands for any application. Additionally, we specialize in targeting various carbohydrate-binding protein receptors, including ASGPR, Galectins and Siglecs, to ensure we provide the precise ligands required for your therapeutic delivery system.

Glycan Ligands Equipped for Conjugation & Immobilization

Interactions where glycans act as ligands and form the basis of specific recognition by glycan-binding proteins (lectins) lie at the heart of glycobiology. We are highly experienced in synthesizing a wide variety of glycans equipped with functionalized linkers, including biotin, amine, carboxylic acid, and click chemistry substrates (such as azides, DBCO and
terminal alkynes), as well as maleimide, oxazolines, and thiol groups. We can also incorporate a variety of defined spacers, including short alkyl spacers or monodisperse (discrete) polyethylene glycol (PEG) of any length between the glycan and functional group.

Common Glycan Structures

Glycans exhibit enormous structural diversity, yet, among this complexity certain structures share common monosaccharide sequences and linkage patterns. These common glycan structures include various terminal epitopes, linear extensions and core structures such as those found on N- and O-linked glycoproteins, glycolipids, and glycosaminoglycans. We offer an extensive portfolio of glycan products representing the diversity of these common glycan structures including Alpha-Gal, LacNAc (Poly-LacNAc), Blood Groups, N-linked Glycans, O-linked Glycans, Sialosides and Glycosaminoglycans.

Glycoamino Acids

Glycosylated amino acids are essential reagents for the
synthesis of glycopeptides and as standards to study the properties of these important biomolecules. For over 25 years, we have offered researchers the most extensive selection of high-purity, commercially available glycosylated amino acids.

Glycopeptide & Peptides

We are globally recognized as the premier producer of synthetic, precisely defined and characterized glycosylated peptides. We also manufacture the high-quality glycoamino acid building blocks essential for glycopeptide synthesis. With nearly two decades of experience, we have refined our techniques for both N-and O-linked glycopeptides. Our capabilities extend to a diverse array of peptide types, including lipopeptides, glycolipopeptides, macrocyclic peptides, fructosylated peptides, peptides labeled with fluorescent or biotin markers, as well as peptides tagged with stable isotopes. This expertise enables us to deliver unparalleled quality and customization in glycopeptide synthesis for a wide range of applications.

Neo-glycoprotein Conjugates

Neo-glycoproteins and neo-glycopeptides are synthetic
glycoconjugates with non-native glycan linkages and altered glycan structures. We synthesize neo- glycoproteins by conjugating a wide range of glycans, both natural and non-natural, to proteins such as bovine serum albumin (BSA), keyhole limpet hemocyanin (KLH) and others. These glycans can be attached to the protein using various chemistries, including amine-reactive, thiol-reactive and click-chemistry methods.

Glycan Probes

Glycan-based probes are specialized molecular tools designed to investigate the selectivity of glycan binding proteins and the activity of carbohydrate active enzymes (CAZymes) including glycosidases and glycosyltransferases. We provide probes that can be used to screen recombinantly expressed proteins or in cell-based assays.

Lipopolysaccharides

Lipopolysaccharides are important outer membrane components of gram-negative bacteria. They are large amphipathic glycoconjugates that typically consist of a lipid domain (hydrophobic) attached to a core oligosaccharide and a distal polysaccharide. These molecules are also known as lipogylcans due to the presence of lipid and sugar molecules.

Pharmaceutical Standards

We provide high-quality pharmaceutical reference standards essential for accurate quantitation, qualification and bioanalytical assessments. Our standards support research in active pharmaceutical ingredients (APIs), metabolites, new chemical entities (NCEs) and internal standards across diverse bioanalytical methods. With a focus on precision, reliability, and global trust, our portfolio of pharmaceutical standards
includes stable isotope-labelled compounds (deuterated, 13C and 15N), glucuronides and vitamin standards.

Want to learn about our services?

While our product portfolio boasts a variety of high-quality carbohydrate-based products, our Contract Research Organization (CRO) and Custom Synthesis services offer tailored solutions.

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