A peracetylated β-D-N-acetylgalactosamine (GalNAcβ) ligand equipped with an azide-functionalized linker through a short ethyl spacer, with the sugar hydroxyl groups protected as acetate esters. The peracetate groups increase lipophilicity to facilitate cell membrane permeability. The terminal azide can be covalently coupled to alkyne partners via copper-catalyzed azide-alkyne cycloaddition (CuAAC), or to dibenzocyclooctyne (DBCO) and related strained alkynes using copper-free click chemistry, forming stable 1,2,3-triazole linkages. This compound enables the construction of hepatocyte-targeted therapeutics and research tools that exploit the asialoglycoprotein receptor (ASGPR), which is highly expressed on liver hepatocytes and binds GalNAc-containing ligands with high affinity. In its peracetylated form, the probe is also suited to metabolic glycoengineering and cell-based studies where membrane permeability is required prior to intracellular deprotection.