GalNAcβ Ligands
N-acetylgalactosamine (GalNAcβ) ligands can be used to target drugs to hepatocytes in the liver, by exploiting the asialoglycoprotein receptor (ASGPR). ASGPR has a high affinity for GalNAc-containing ligands. Therapeutic payloads can be directly conjugated to GalNAc ligands or encapsulated in nanoparticles decorated with GalNAc ligands.
We provide GalNAcβ ligands with various functional linkers depending on their intended use.
