A β-D-N-acetylgalactosamine (GalNAcβ) ligand equipped with an N-hydroxysuccinimide (NHS) activated ester through a hydrophilic PEG3 spacer. The NHS ester reacts with primary amines to form stable amide bonds for single-step conjugation to amine-bearing payloads and surfaces. This compound enables the construction of hepatocyte-targeted therapeutics and research tools that exploit the asialoglycoprotein receptor (ASGPR), which is highly expressed on liver hepatocytes and binds GalNAc-containing ligands with high affinity.
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Technical Data
CAS #: N/A
Formula: C19H30N2O12
Molecular Weight: 478.45
Ester Activity: >50%
Storage & Shipping
Shipping requirement: Ambient
Storage conditions: -20°C
Other Names
β-GalNAc-PEG3-N-hydroxysuccinimide ester; 2-[2-(2-Carboxyethoxy)ethoxy]ethyl 2-acetamido-2-deoxy-β-D-galactopyranoside NHS ester; (8-Carboxy-3,6-dioxaoctyl) 2-acetamido-2-deoxy-β-D-galactopyranoside NHS ester; Omega-carboxy-triethyleneglycol-2-acetamido-2-deoxy-β-D-galactopyranoside NHS ester
For research and development use only
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