A triantennary N-acetylgalactosamine (Tri-GalNAcβ) ligand connected through a γ-aminobutyric acid (GABA) linker and a 2-kDa polyethylene glycol (PEG2000) spacer to 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE), a phospholipid anchor. The DSPE moiety inserts into lipid bilayers, enabling decoration of liposomes, lipid nanoparticles (LNPs), and other lipid-based delivery vehicles with a surface-displayed Tri-GalNAc targeting ligand. This compound enables the construction of hepatocyte-targeted therapeutics and research tools that exploit the asialoglycoprotein receptor (ASGPR; Ashwell-Morell receptor), which is highly expressed on liver hepatocytes and binds GalNAc-containing ligands with high affinity. The trivalent presentation of GalNAcβ residues engages multiple carbohydrate-recognition domains of ASGPR simultaneously, producing high-avidity binding that substantially exceeds the affinity of monovalent GalNAc ligands and closely mimics the geometry of clinically validated Tri-GalNAc targeting moieties used in approved GalNAc-siRNA therapeutics. Tri-GalNAc-PEG2000-DSPE enables the construction of liver-targeted liposomes and LNPs for delivery of therapeutic agents to hepatocytes, with applications in hepatitis, liver cancer, and metabolic disorder research, aiming to improve the therapeutic index of drugs by enhancing accumulation in the liver while minimizing exposure to non-target tissues. We inventory this product. For bulk pricing including gram quantities, please inquire.