GP900055

MUC1(127-146)-Core 3(139,140)

MUC1 (UniProt ID P15941) synthetic glycopeptide fragment (Ala127-Pro146; UniProt position 127-146, aa length 20) from the tandem repeat (TR) region of the MUC1 protein. The fragment contains tumor-associated carbohydrate antigen (TACA), Core-3 antigen, O-glycosylation (GlcNAcβ1-3GalNAc) at Thr139 and Ser140. The C-terminus is an amide.

Sequence:

APGSTAPPAHGVT*S*APDTRP-NH₂
H-Ala-Pro-Gly-Ser-Thr-Ala-Pro-Pro-Ala-His-Gly-Val-Thr*-Ser*-Ala-Pro-Asp-Thr-Arg-Pro-NH₂

where T* = Thr* = GlcNAcβ1-3GalNAcα-O-Thr and S* = Ser* = GlcNAcβ1-3GalNAcα-O-Ser