GP100082: Cys-MUC1(126-145)-Tn(130,131,139,140,144)

GP100082

Cys-MUC1(126-145)-Tn(130,131,139,140,144)

MUC1 (UniProt ID P15941) synthetic glycopeptide fragment (Pro126-Arg145; UniProt position 126-145, aa length 20) from the tandem repeat (TR) region of the MUC1 protein. The fragment contains tumour-associated carbohydrate antigen (TACA), Tn-antigen, O-glycosylation (α-GalNAc) at Ser130, Thr131, Thr139, Ser140 and Thr144. Cys is conjugated at the N-terminal of peptide sequence. The C-terminus is an amide.

Sequence:

CPAPGS*T*APPAHGVT*S*APDT*R-NH₂
H-Cys-Pro-Ala-Pro-Gly-Ser*-Thr*-Ala-Pro-Pro-Ala-His-Gly-Val-Thr*-Ser*-Ala-Pro-Asp-Thr*-Arg-NH₂

where S* = Ser* = GalNAcα-O-Ser, T* = Thr* = GalNAcα-O-Thr