GP100080

MUC1(126-149)-Tn(130,131,144)

MUC1 (UniProt ID P15941) synthetic glycopeptide fragment (Pro126-Gly149; UniProt position 126-149, aa length 24) from the tandem repeat (TR) region of the MUC1 protein. The fragment contains tumor-associated carbohydrate antigen (TACA), Tn-antigen, O-glycosylation (α-GalNAc) at Ser130, Thr131 and Thr144. The C-terminus is carboxylic acid.

Sequence:

PAPGS*T*APPAHGVTSAPDT*RPAPG-OH
H-Pro-Ala-Pro-Gly-Ser*-Thr*-Ala-Pro-Pro-Ala-His-Gly-Val-Thr-Ser-Ala-Pro-Asp-Thr*-Arg-Pro-Ala-Pro-Gly-OH

where S* = Ser* = GalNAcα-O-Ser, T* = Thr* = GalNAcα-O-Thr