An α-L-rhamnose ligand equipped with a thiol-functionalized linker through a short ethyl spacer. The thiol group can be reacted with other thiol-modified substrates to form disulfide bonds, or reacted with maleimides to form stable thioether conjugates. This compound provides an α-L-rhamnose building block for glycoconjugate synthesis and the construction of probes that exploit naturally occurring anti-rhamnose antibodies, with applications in antibody-recruiting molecule and immunotherapy research.