GP000041: Biotin-PEG2-Gly-MUC1(126-149)-STn(139,144)

GP000041

Biotin-PEG2-Gly-MUC1(126-149)-STn(139,144)

Name: GP000041: Biotin-PEG2-Gly-MUC1(126-149)-STn(139,144)
Brand: Sussex Research Laboratories Inc.
Availability: OutOfStock

MUC1 (UniProt ID P15941) biotinyl synthetic glycopeptide fragment (Pro126-Gly149; UniProt position 126-149, aa length 24) from the variable number tandem repeat (TR) domain. Tumour-associated carbohydrate antigen (TACA), Sialyl Tn or STn antigen (Neu5Acα2-6GalNAcα1-O-Thr) at Thr139 and Thr144. Biotin is conjugated at the N-terminus and is separated from the peptide sequence by a discrete, monodisperse and amphiphilic diethylene glycol (PEG2) and glycine spacer. The C-terminus is a carboxylic acid.

Sequence:

Biotin-PEG2-G-PAPGSTAPPAHGVT*SAPDT*RPAPG-OH
Biotin-PEG2-Gly-Pro-Ala-Pro-Gly-Ser-Thr-Ala-Pro-Pro-Ala-His-Gly-Val-Thr*-Ser-Ala-Pro-Asp-Thr*-Arg-Pro-Ala-Pro-Gly-OH

where T* = Thr* = Thr(Sialyl Tn) = Thr(STn) = Neu5Acα2-6GalNAcα-O-Thr