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GA131020

In Stock

Fmoc-Thr(Neu5Acα(2-3)Galβ(1-3)GalNAc)-OH (Peracetate, Methyl Ester)

Tumor-Associated Carbohydrate Antigen (TACA). STF-antigen (also ST) is a sialylated form of the truncated O-glycosylated core determinant TF (also T) with structure: Neu5Acα2-3Galβ1-3GalNAcα-O-Ser/Thr. STF results from an early sialylation of the TF antigen due to overexpression of the enzyme α2,3sialylT and/or disruption of further glycan elongation processes. STF is negligibly expressed in healthy tissues but overexpressed in human carcinomas . As such, STF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered STF a prime target for cancer immunotherapy.

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$5,000.00 USD
$5,000.00 USD
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  • Other Names

    STF Epitope (Threonine); STF Antigen (Threonine); ST Antigen; Sialyl-T Antigen; Fmoc-Thr(α-L-Neu5Ac(Ac)4-(2-3)-β-D-Gal(Ac)3-(1-3)-α-D-GalNAc(Ac)2)-OH; ST Antigen (Fmoc-Threonine, Peracetate, Methyl ester); α(2,3)Sialyl TF Antigen (Fmoc-Threonine, Peracetate, Methyl ester); Neu5Acα(2,3)Galβ(1,3)GalNAcα–Thr (Fmoc, Peracetate, Methyl ester); Nα-(Fluoren-9-ylmethoxycarbonyl)-O-[(methyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonate)-(2→3)-2,4,6-tri-O-acetyl-β-D-galactopyranosyl-(1→3)-2-N-acetamido-2-deoxy-4,6-di-O-acetyl-α-D-]-L-threonine

  • Technical Data

    CAS #: 125760-33-0

    Formula: C63H79N3O32

    Molecular Weight: 1390.3

    Purity: >95% (HPLC)

  • Storage & Shipping

    Shipping requirement: Dry Ice

    Storage conditions: -20°C

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