An α-D-mannose ligand equipped with an amine-functionalized linker through a short ethyl spacer. The primary amine can be covalently coupled with N-hydroxysuccinimide (NHS) activated esters to form stable amide bonds, providing a straightforward route to conjugate the ligand onto NHS-activated molecules and surfaces. This compound provides an α-D-mannose building block for glycoconjugate synthesis and the construction of probes for mannose-recognizing receptors and lectins, including the mannose receptor (CD206) and DC-SIGN, with relevance to immune targeting and pathogen-recognition research.