GalNAcα glycoamino acids are pivotal for glycopeptide synthesis to incorporate N-acetylgalactosamine moieties into peptide chains. These building blocks can be used as ligands of glycan binding proteins, standards or for the precise synthesis of glycopeptides containing the GalNAcα epitope, which forms the class of O-linked GalNAc glycosylated glycoproteins. This approach facilitates the study of glycoprotein interactions and the development of glycopeptide-based drugs with enhanced specificity and efficacy, especially in targeting galactose-binding proteins like the asialoglycoprotein receptor (ASGPR).
