Alpha-Gal (Galα1-3Galβ1-4GlcNAcβ) Ligands

Galα1-3Glcβ1-4GlcNAc (alpha-Gal) epitope is a disaccharide unit composed of a galactose-alpha-1,3-galactose sequence. It is a naturally abundant structure found on glycolipids and glycoproteins on the cell surface of non-primate mammals. Humans can develop IgE antibodies against alpha-Gal epitopes following repeated exposure and sensitization can lead to alpha-Gal syndrome that presents serious challenges to human health. Ongoing research focuses on understanding the mechanisms of alpha-Gal sensitization, the role of tick bites, and potential treatment or desensitization strategies.

We provide alpha-Gal ligands with various functional linkers depending on their intended use.