GalNAcα Ligands
N-acetylgalactosamine (GalNAcα) ligands can be used to target drugs to hepatocytes in the liver, by exploiting the asialoglycoprotein receptor (ASGPR). ASGPR has a high affinity for GalNAc-containing ligands. Therapeutic payloads can be directly conjugated to GalNAc ligands or encapsulated in nanoparticles decorated with GalNAc ligands.
Terminal GalNAcα ligands are substrates for glycosyltransferases, including galactosyltransferases and sialyltransferases.
We provide GalNAcα ligands with various functional linkers depending on their intended use.
