Mannose-6-phosphate (M6P) glycan is a crucial signal for the trafficking of lysosomal enzymes to lysosomes and is recognized by M6P receptors (MPRs). The resulting enzyme-MPR complex is delivered to early endosomes. Development of therapeutic enzymes for lysosomal storage diseases require M6P glycans for cellular uptake and lysosomal targeting.
Other Names:
M6P-PEG3-Propyne;
2-{2-[2-(Prop-2-ynyloxy)ethoxy]ethoxy}ethyl mannose-6-phosphate;
(Dodec-11-yn-3,6,9-trioxadodecyl) α-D-mannose-6-phosphate
