Fluorinated glucosamine has been shown to block the synthesis of key carbohydrate structures linked to cancer progression via interference with UDP-GlcNAc synthesis. The anomerically racemic 4-F-GlcNAc is an inhibitor of hepatic glycosaminoglycan biosynthesis and used as a probe for the study of protein-carbohydrate interactions.
Other Names:
4-F-GlcNAc;
2-Acetamido-2,4-dideoxy-4-fluoro-D-glucopyranose (mixed anomers)
References:
S.R. Barthel et al., The Journal of Biological Chemistry 2011, 286, 21717–21731.
