Product #: MV100050
Tri-GalNAc-PEG5-COOH
Tri-GalNAc-COOH serves a pivotal role in the innovative realm of lysosomal targeting chimera (LYTAC) technology. This specialized compound is engineered as an effective asialoglycoprotein receptor (ASGPR) ligand. This trivalent β-GalNAc Ligand has a discrete, monodisperse, carboxyl-functionalized pentaethyleneglycol (PEG5) linker/spacer. This structure is specifically tailored for attachment to a targeted protein ligand, paving the way for the creation of advanced therapeutic strategies. These strategies exploit the mechanism of guiding molecules directly to lysosomes, facilitating their degradation. The utility of Tri-GalNAc-COOH in this cutting-edge research underscores its significance in the quest for targeted treatment modalities.
Other Names: (β-D-GalNAc-sp)3-NHC(O)-PEG5-COOH; Triantennary β-D-GalNAc pentaethyleneglycol (PEG5) carboxylic acid ligand; tri-GalNAc COOH; tri-GalNAc-COOH; tri-GalNAc-CO2H; Trivalent GalNAc-COOH
References: Development of Triantennary N Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins Yaxian Zhou, Peng Teng, Nathan T. Montgomery, Xiaolei Li, and Weiping Tang ACS Cent. Sci. 2021, 7, 499−506
$500.00 USD
Product Details
-
Technical Data
CAS #: 1953146-81-0
Formula: C75H134N10O35
Molecular Weight: 1735.9
Purity: >95% (HPLC)
-
Storage & Shipping
Shipping requirement: Ambient
Storage conditions: -20°C
-
Documentation
Email: info@sussex-research.com