Glycopeptides offer a unique frontier for research & development. The critical role of glycan elements on cell surface proteins and those bound to circulatory proteins is well recognized. Carbohydrates on proteins mediate a host of biological events including cell adhesion, immune system function, fertilization, cellular targeting as well as protein transport, stabilization, and half-life. Thus, the use of synthetic glycoproteins or their fragments (glycopeptides) as experimental probes for basic research and biomedical applications is growing rapidly.
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Learn more about Glycopeptides & Peptides
At Sussex Research Laboratories Inc., we stand at the cutting edge of glycopeptide synthesis, cementing our status as the world's leading provider of synthetic, precisely defined, and characterized glycosylated peptides. With nearly two decades of dedicated effort, we have refined our synthesis techniques to master both N- and O-linked glycopeptides. Our expertise does not end there; we specialize in a broad spectrum of peptides including lipopeptides, glycolipopeptides, macrocyclic peptides, fructosylated peptides, and peptides tagged with fluorescent or biotin markers, as well as peptides labeled with stable isotopes.
Unlocking Potentials in Research & Development
Glycopeptides are revolutionizing the research and development landscape, highlighting the critical roles of glycans in cell-surface and circulatory proteins. These carbohydrates are pivotal in various biological processes such as cell adhesion, immune responses, fertilization, and cellular targeting. They are essential for the transport, stabilization, and lifespan of proteins. Consequently, synthetic glycoproteins and glycopeptide fragments have become indispensable tools for fundamental research and biomedical applications, witnessing a swift expansion in their usage.
Advancing Drug Discovery & Development
The glycosylation of peptides considerably enhances their stability, solubility, and bioavailability, often amplifying the effectiveness of peptide-based therapies. Such modifications endow peptides and proteins with beneficial biological properties, making short, stable, and well-characterized glycopeptide sequences derived from larger proteins highly efficient as ligands.
Our Glycopeptide Expertise
As a frontrunner in glycopeptide synthesis, we boast an extensive expertise in glycopeptides, including but not limited to:
Mucins like MUC1 and glycopeptides associated with cancer
Erythropoietin analogs
Fragments of the RNA polymerase II C-Terminal Domain
Glycopeptides from the IgA Hinge domain
PSGL-1 mimetics
Frizzled 8 analogs (FRZD8 or Antiproliferative factor)
O-GlcNAc-modified nucleocytoplasmic protein fragments
Glycated hemoglobin fragments
Synthetic O-Linked Glycopeptides
O-linked glycopeptides and proteins, essential on cell surfaces and in extracellular proteins, predominantly involve the attachment of N-acetylgalactosamine (alpha-GalNAc) to Ser or Thr. Other types of O-glycosylation, crucial in early development and protein functions, are also a part of our repertoire.
Synthetic N-Linked Glycopeptides
N-linked glycosylation, a key post-translational modification in eukaryotes and archaea, is instrumental in protein folding. A significant portion of human therapeutic proteins, benefiting from increased in vivo half-life and bioavailability due to N-linked glycans, contains these modifications.
Glycated Peptides
Peptide glycation, the non-enzymatic attachment of sugars to proteins, is a process implicated in various complications associated with diabetes, aging, and other conditions. This area is another expertise of ours, highlighting our comprehensive capabilities in glycopeptide synthesis.
IVGVVEPVPHDET*Y-NH2
Where T* = Thr* = GalNAcα-O-Thr
hACE2(484-497)-Tn(496)
Product #: GP100300
UniProt ID: A0A7I2V2E9
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IEEQAKTFLDKFNHEAEDLFYQS-NH2
hACE2(21-43)-ng
Product #: GP100301
UniProt ID: Q5RFN1
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NFSQILPDPSKPSKR-NH2
SPIKE-SARS2(801-815)
Product #: GP100325
UniProt ID: P0DTC2
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HSDGIFTDSYSRYRKQMAVKKYLAAVL-NH2
PACAP(132-158)
Product #: GP100350
UniProt ID: P18509
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HSDGIFTDSYSRYRKQMAVKKYLAAVLS*-NH2
Where S* = Ser* = GalNAcα-O-Ser
PACAP(132-158)-Ser(GalNAc)
Product #: GP100351
UniProt ID: P18509
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DVST*PPTVLPDNFPRYPVG-OH
Where T* = Thr* = GalNAcα-O-Thr
IGF2(93-111)-Tn(96)
Product #: GP100375
UniProt ID: A8K6C9
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DVS*TPPTVLPDNFPRYPVG-OH
Where S* = Ser* = GalNAcα-O-Ser
IGF2(93-111)-Tn(95)
Product #: GP100376
UniProt ID: A8K6C9
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T*PAPLDSVFSSSERAHQVLR-OH
Where T* = Thr* = GalNAcα-O-Thr
PROC(19-38)-Tn(19)
Product #: GP100400
UniProt ID: E7END6
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YSPTS*PSK-NH2
where S* = Ser* = GlcNAcβ-O-Ser
RPB1 CTD(1615-1621-Lys)-GlcNAc(1619)
Product #: GP200000
UniProt ID: P24928
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SVES*GSADAK-NH2
where S* = Ser* = GlcNAcβ-O-Ser
Uncharacterized Protein 1 (1179-1188)-GlcNAc(1182)
Product #: GP200005
UniProt ID: A0A2J5HJ78
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SVET*GSADAK-NH2
where T* = Thr* = GlcNAcβ-O-Thr
Uncharacterized Protein Analogue (1179-1188)-GlcNAc(1182)
Product #: GP200010
UniProt ID: A0A2J5HJ78
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VKSKIGS*TENLKC-NH2
where S* = Ser* = GlcNAcβ-O-Ser
MAPT(573-584-Cys)-GlcNAc(579)
Product #: GP200015
UniProt ID: P10636
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VKSKIGSTENLKC-NH2
No glycosylation
MAPT(573-584-Cys)
Product #: GP200016
UniProt ID: P10636
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NYIVGQPSS*TGNL-OH
where S* = Ser* = GlcNAcβ-O-Ser
Synthetic Glycopeptide 1
Product #: GP200020
UniProt ID: N/A
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NYSVPSS*TGNL-OH
where S* = Ser* = GlcNAcβ-O-Ser
Synthetic Glycopeptide 2
Product #: GP200025
UniProt ID: N/A
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TCPVQLWVDS*TPPPGTR-NH2
where S* = Ser* = GlcNAcβ-O-Ser
TP53(140-156)-GlcNAc(149)
Product #: GP200030
UniProt ID: P04637
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CGRTAPTST*IAPG-NH2
where T* = Thr* = GlcNAcβ-O-Thr
Cys-Gly-CREB-1(241-251)-GlcNAc(247)
Product #: GP200035
UniProt ID: P16220
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CGRTAPTS*TIAPG-NH2
where S* = Ser* = GlcNAcβ-O-Ser
Cys-Gly-CREB-1(241-251)-GlcNAc(246)
Product #: GP200040
UniProt ID: P16220
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CGRTAPT*STIAPG-NH2
where T* = Thr* = GlcNAcβ-O-Thr
Cys-Gly-CREB-1(241-251)-GlcNAc(245)
Product #: GP200045
UniProt ID: P16220
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Ac-CDTSPAAPVS*YADMRTGZ-NH2
where S* = Ser* = GlcNAcβ-O-Ser
Ac-Cys-IRS1(1003-1018)-GlcNAcβ(1011)-Z
Product #: GP200050
UniProt ID: P35568
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AET*PALSESDSTEAFR-NH2
where T* = Thr* = GlcNAcβ-O-Thr
Synthetic Glycopeptide 3
Product #: GP200055
UniProt ID: N/A
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CIVATS*TQGSV-OH
where S* = Ser* = GlcNAcβ-O-Ser
Foxp3(280-290)-GlcNAc(285)-Mouse
Product #: GP200060
UniProt ID: Q99JB6
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SRN*TRD-NH2
where N* = Asn* = GlcNAcβ-N-Asn
DTNB(636-641)-GlcNAc(638)-Rat
Product #: GP200065
UniProt ID: P84060
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LNN*GT-NH2
where N* = Asn* = GlcNAcβ-N-Asn
Zswim3(41-45)-GlcNAc(43)-Mouse
Product #: GP200075
UniProt ID: Q8CFL8
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