MUC1(126-149)-STn(130,131,144)

MUC1 (UniProt ID P15941) synthetic glycopeptide fragment (Pro126-Gly149; UniProt position 126-149, aa length 24) from the variable number tandem repeat (TR) domain. The fragment contains tumour-associated carbohydrate antigen (TACA), Sialyl Tn or sTn (Neu5Acα2-6GalNAcα-O-Ser) at Ser130, Neu5Acα2-6GalNAcα-O-Thr at Thr131 and Thr144. The C-terminus is carboxylic acid.

Sequence:

PAPGS*T*APPAHGVTSAPDT*RPAPG-OH
H-Pro-Ala-Pro-Gly-Ser*-Thr*-Ala-Pro-Pro-Ala-His-Gly-Val-Thr-Ser-Ala-Pro-Asp-Thr*-Arg-Pro-Ala-Pro-Gly-OH
where S* = Ser* = Ser(Sialyl Tn) = Ser(STn) = Neu5Acα2-6GalNAcα-O-Ser and T* = Thr* = Thr(Sialyl Tn) = STn = Neu5Acα2-6GalNAcα-O-Thr