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Glycopeptides & Peptides
Glycopeptides are at the cutting edge of research and development in human health and biomedical science, largely due to the critical roles of glycan components on cell surface and circulating proteins. Glycopeptides provide distinct advantages over standard peptides, playing a crucial role in enhancing therapeutic strategies, optimizing drug formulations, and deepening our understanding of complex biological processes. Their diverse functions in health and disease highlight their importance in biomedical research and practical applications. Glycopeptides are being studied as biomarkers for diseases such as cancer and autoimmune disorders, with alterations in glycosylation patterns aiding early diagnosis and personalized treatment. Glycopeptides are also being leveraged in vaccine development and as targeted therapies for cancer. These carbohydrate structures are essential for a range of biological functions, including cell recognition, signaling, immune responses, development, and differentiation. Additionally, they enhance protein stability and solubility, facilitate fertilization, mediate interactions with pathogens, and influence protein folding, thermal stability, biological activity, viscosity, and transport.
Recent developments in glycopeptides have highlighted their significant roles in human health and research, showcasing their potential in various applications:
1. Therapeutic Application
Cancer Treatment: Glycopeptides are being explored as targeted therapies for cancer. Their unique glycan structures can enhance specificity for cancer cells, improving the efficacy of drugs while minimizing side effects.
Vaccines: Glycopeptides are increasingly used in vaccine development. Their ability to mimic natural glycan patterns on pathogens helps stimulate stronger immune responses.
2. Disease Diagnostics
Biomarkers: Glycopeptides are being studied as biomarkers for various diseases, including cancer and autoimmune disorders. Changes in glycosylation patterns can indicate disease presence or progression, aiding in early diagnosis and personalized treatment.
3. Understanding Biological Mechanisms
Cellular Interactions: Research is revealing how glycopeptides influence cell signaling and communication. This understanding is crucial for unraveling the mechanisms behind immune responses and cellular differentiation.
Microbiome Interactions: Glycopeptides are being investigated for their roles in host-microbe interactions, particularly how they affect gut health and metabolic processes.
4. Drug Development
Enhanced Bioavailability: Glycosylation can improve the stability and solubility of therapeutic peptides, leading to better bioavailability and efficacy. This is particularly important for peptide-based drugs that may otherwise degrade quickly in the body.
5. Advanced Research Tools
Experimental Probes: Synthetic glycopeptides are being developed as experimental probes to study glycan-related processes in cells. This includes understanding glycan-protein interactions and their effects on cellular behavior.
High-Throughput Screening: Innovations in glycopeptide synthesis are enabling high-throughput screening methods, accelerating the discovery of new therapeutics and biological insights.
6. Nutritional and Functional Foods
Dietary Glycopeptides: Research is uncovering the health benefits of glycopeptides derived from dietary sources, suggesting they may play roles in enhancing gut health and modulating immune functions.
7. Beauty & Cosmetics
Cosmetic glycopeptides are gaining popularity in skincare formulations for their ability to enhance skin health and appearance. By promoting collagen and elastin production, they improve skin elasticity and firmness. Particularly effective in anti-aging products, glycopeptides target fine lines and wrinkles while also enhancing overall skin texture.
We offer a diverse portfolio of glycopeptides, readily available for various applications. Explore our selection or request custom synthesis to ensure the perfect fit for your specific needs.
By Application
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Cancer Biomarkers
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Kidney Disease Biomarkers
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Neuro Disease Biomarkers
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Other Biomarkers
Custom Synthesis
We are leaders in glycopeptide synthesis and are globally recognized as the premier provider of synthetic, precisely defined, and characterized glycosylated peptides. Our in-house facility allows us to produce high-quality glycoamino acid building blocks that are essential for glycopeptide synthesis. Our esteemed team of carbohydrate and peptide experts is dedicated to meeting the increasing demand for glycopeptides. With nearly two decades of experience, we have refined our techniques for both N- and O-linked glycopeptides. Additionally, our expertise extends to a diverse array of peptides, including lipopeptides, glycolipopeptides, macrocyclic peptides, fructosylated peptides, and those labeled with fluorescent or biotin markers, as well as peptides tagged with stable isotopes.
Some of the notable Glycopeptides and Peptides that we synthesized : Mucin Glycopeptides (MUC1, MUC2, MUC3A, MUC4, MUC5Ac, MUC7, MUC16), CD Glycopeptides (CD19, CD24 and CD99), Alpha-Fetoprotein (AFP), Alpha-Dystroglycan (DAG1), Insulin Like Growth Factor 2 (IGF2), Immunoglobulin A (IgA1), Human Angiotensin Converting Enzyme (HACE2), Alanine and Proline rich (APA), Erythropoietin (EPO), Alpha-2 HS-Glycoprotein (AHSG or Fetuin A), Alpha-2 HS-Glycoprotein (AHSG or Fetuin A), PSGL-1 mimetic, Hemoglobin Subunit Beta (HBB), Herpes Simplex Virus (HSV-1 or HHV-1), Lanreotide, Terlipressin, Octreotide, Semaglutide, Tirzepatide etc.
Synthetic O-Linked Glycopeptides
O-linked glycopeptides and proteins, essential on cell surfaces and in extracellular proteins, predominantly involve the attachment of N-acetylgalactosamine (alpha-GalNAc) to Ser or Thr. Other types of O-glycosylation, crucial in early development and protein functions, are also a part of our repertoire.
Synthetic N-Linked Glycopeptides
N-linked glycosylation, a key post-translational modification in eukaryotes and archaea, is instrumental in protein folding. A significant portion of human therapeutic proteins, benefiting from increased in vivo half-life and bioavailability due to N-linked glycans, contains these modifications.
Glycated Peptides
Peptide glycation, the non-enzymatic attachment of sugars to proteins, is a process implicated in various complications associated with diabetes, aging, and other conditions. This area is another expertise of ours, highlighting our comprehensive capabilities in glycopeptide synthesis.
Synthetically Challenging Glycopeptides
Certain glycopeptides pose significant synthetic challenges due to their intricate structures and unique glycosylation patterns. Our team is prepared to elevate your research by tackling these complexities head-on:
Highly Branched Glycopeptides: With multiple glycan attachments, their synthesis is intricate, requiring precise control over glycosylation reactions.
Non-Canonical Glycopeptides: The incorporation of unusual sugars or linkages complicates synthesis and purification, necessitating advanced synthetic strategies.
Multi-Functional Glycopeptides: Designed for diverse biological roles, these peptides demand intricate architectures that standard methods struggle to achieve.
Post-Translationally Modified Glycopeptides: These peptides undergo various modifications that are challenging to replicate synthetically, requiring sophisticated techniques to mimic natural processes.
In addition to our glycopeptide services, we offer custom peptide synthesis for synthetically challenging peptides from microgram to gram scale. We can synthesize a diverse range of structures, including linear, branched, dendrimeric, macrocyclic, multicyclic, phosphorylated, sulfated, biotinylated, fluorinated, isotope labelled and lipopeptides. If you’re looking for a unique research project involving glycoforms, amino acids, linker systems, specific sequences, modifications, or particular probes or labels, we are ready to help turn your vision into reality.
We're here to help!
Seeking multiple distinct custom glycopeptides or peptide sequences, along with specific modifications, for your research or project? Explore our versatile synthesis services.