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Thiamet-G Dimethyl Analog

Thiamet-G Dimethyl Analog molecular structure

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IN200010-250MG250mgIn StockInquire
IN200010-500MG500mgIn StockInquire
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Product Details

Name Thiamet-G Dimethyl Analog
Product No.IN200010
Synonym(s) (3aR,6S,7R,7aS)-2-(Dimethylamino)-5,6,7,7a-tetrahydro-5-(hydroxymethyl)pyrano[3,2-d]thiazole-6,7-diol
CategoryGlycobiology Tools, Click Chemistry & ProbesInhibitors
FormulaC9H16N2O4S
Molecular Weight248.3
AvailabilityYes
Availability in BulkYes
Purity>95% (HPLC)
DescriptionThiamet-G is a highly selective inhibitor of O-GlcNAc-specific hexosaminidase (O-GlcNAcase) in humans; Thiamet-G may find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological hyperphosphorylation of tau in Alzheimer’s disease
CommentsN-Acetylglucosamine; GlcNAc; O-GlcNAcase Inhibitor; Monosaccharide; Thiazoline
ReferencesS.A. Yuzwa et al., Nature Chemical Biology 2008, 4, 483-490.
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