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Thiamet-G

Thiamet-G molecular structure

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Product Details

Name Thiamet-G
Product No.IN200000
Synonym(s) (3aR,6S,7R,7aS)-2-(Ethylamino)-5,6,7,7a-tetrahydro-5-(hydroxymethyl)pyrano[3,2-d]thiazole-6,7-diol
CategoryGlycobiology Tools, Click Chemistry & ProbesInhibitors
CAS No.1009816-48-1
FormulaC9H16N2O4S
Molecular Weight248.3
AvailabilityYes
Availability in BulkYes
Purity>95% (HPLC)
DescriptionThiamet-G is a highly selective inhibitor of O-GlcNAc-specific hexosaminidase (O-GlcNAcase) in humans; Thiamet-G may find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological hyperphosphorylation of tau in Alzheimer’s disease
CommentsN-Acetylglucosamine; GlcNAc; O-GlcNAcase Inhibitor; Monosaccharide; Thiazoline
ReferencesS.A. Yuzwa et al., Nature Chemical Biology 2008, 4, 483-490.
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