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Fmoc-Thr(β-D-GlcNAc(Ac)₃)-OH

Fmoc-Thr(β-D-GlcNAc(Ac)₃)-OH molecular structure

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SKUPack SizeAvailabilityPriceQuantity
GA231000-50MG50mgIn StockUS$350.00
GA231000-100MG100mgIn StockUS$600.00
GA231000-250MG250mgIn StockUS$1,100.00
GA231000-500MG500mgIn StockUS$1,950.00
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Product Details

Name Fmoc-Thr(β-D-GlcNAc(Ac)₃)-OH
Product No.GA231000
Synonym(s) O-GlcNAc / Threonine; Fmoc-Thr(β-D-GlcNAc)-OH, Peracetate; Fmoc-Thr(GlcNAc(Ac)₃-β-D)-OH; N-α-Fmoc-O-β-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosyl)-L-threonine
CategoryGlycoamino AcidsThreonine
CAS No.160168-40-1
FormulaC33H38N2O13
Molecular Weight670.66
AvailabilityYes
Availability in BulkYes
Purity>95% (HPLC)
DescriptionO-GlcNAc on proteins plays fundamental roles as a cellular nutrient and stress sensor and thus central in the etiologies of chronic diseases of aging, including diabetes, cancer and neurodegenerative disease. In dynamic protein glycosylation, reversible β-O-GlcNAc modification of nuclear and cytoplasmic proteins at serine and threonine controls diverse aspects of cell physiology and is conceptually analogous to phosphorylation.
CommentsN-Acetyl-D-Glucosamine; GlcNAc; O-Link; Monosaccharide; Threonine; Blocked; Amino Acid; Ac
ReferencesHart G.W. et al., Annu. Rev. Biochem., 2011, 80, 825-858; Hart G.W., J. Biol. Chem. 2019, 294, 2211-2231.
Datasheet(s)GA231000_COA.pdf (84.11 KB)
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