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TF Antigen (Threonine, NHAc, Methyl Ester)

TF Antigen (Threonine, NHAc, Methyl Ester) molecular structure

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SKUPack SizeAvailabilityPriceQuantity
GA134000-1MG1mgIn StockUS$475.00
GA134000-2MG2mgIn StockUS$750.00
GA134000-5MG5mgIn StockUS$1,400.00
GA134000-10MG10mgIn StockUS$2,250.00
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Product Details

Name TF Antigen (Threonine, NHAc, Methyl Ester)
Product No.GA134000
Synonym(s) Ac-Thr(α-Galβ(1-3) GalNAc)-OCH₃; T Antigen (Threonine, blocked amino acid)
CategoryGlycoamino AcidsThreonine
FormulaC21H36N2O14
Molecular Weight540.52
AvailabilityYes
Availability in BulkYes
Purity>95% (NMR)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy.
CommentsN-Acetyl-D-Galactosamine; O-Link; Disaccharide; Threonine; Blocked; Amino Acid; Ac
Datasheet(s)GA134000_COA.pdf (85.918 KB)
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