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STF Antigen (Threonine, Fmoc, Methyl Ester, Peracetylated)

STF Antigen (Threonine, Fmoc, Methyl Ester, Peracetylated) molecular structure

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SKUPack SizeAvailabilityPriceQuantity
GA131020-25MG25mgIn StockUS$5,000.00
GA131020-50MG50mgIn StockUS$7,500.00
GA131020-100MG100mgIn StockUS$12,750.00
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Product Details

Name STF Antigen (Threonine, Fmoc, Methyl Ester, Peracetylated)
Product No.GA131020
Synonym(s) Fmoc-Thr(Neu5Acα2-3Galβ1-3GalNAc)-OH (peracetylated, methyl ester); ST Antigen (Fmoc-Threonine, Peracetate, Methyl ester); α(2,3)Sialyl TF Antigen (Fmoc-Threonine, Peracetate, Methyl ester); Neu5Acα(2,3)Galβ(1,3)GalNAcα–Thr (Fmoc, Peracetate, Methyl ester); Nα-(Fluoren-9-ylmethoxycarbonyl)-O-[(methyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonate)-(2→3)-2,4,6-tri-O-acetyl-β-D-galactopyranosyl-(1→3)-2-N-acetamido-2-deoxy-4,6-di-O-acetyl-α-D-]-L-threonine
CategoryGlycoamino AcidsThreonine
CAS No.125760-33-0
FormulaC63H79N3O32
Molecular Weight1390.3
AvailabilityYes
Availability in BulkYes
Purity>90% (HPLC)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). STF-antigen (also ST) is a sialylated form of the truncated O-glycosylated core determinant TF (also T) with structure: Neu5Acα2-3Galβ1-3GalNAcα-O-Ser/Thr. STF results from an early sialylation of the TF antigen due to overexpression of the enzyme α2,3sialylT and/or disruption of further glycan elongation processes. STF is negligibly expressed in healthy tissues but overexpressed in human carcinomas . As such, STF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered STF a prime target for cancer immunotherapy.
CommentsN-Acetyl-D-Galactosamine; O-Link; Trisaccharide; Threonine; Blocked; Amino Acid; Ac; Me
Datasheet(s)GA131020_COA.pdf (89.684 KB)
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