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TF Antigen (Threonine, Fmoc, Peracetylated)

TF Antigen (Threonine, Fmoc, Peracetylated) molecular structure

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SKUPack SizeAvailabilityPriceQuantity
GA131010-25MG25mgIn StockUS$750.00
GA131010-100MG100mgIn StockUS$1,985.00
GA131010-250MG250mgIn StockUS$4,000.00
GA131010-500MG500mgIn StockUS$6,450.00
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Product Details

Name TF Antigen (Threonine, Fmoc, Peracetylated)
Product No.GA131010
Synonym(s) T Antigen (Threonine); Fmoc-Thr(β-Gal(Ac)₄-(1-3)-α-GalNAc(Ac)₂)-OH; Fmoc-Thr(α-Gal β(1-3)GalNAc)-OH, Peracetate; O-{2-N-acetyl-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-4,6-di-O-acetyl-2-deoxy-α-D-galactopyranosyl}-Nα-(fluoren-9-yl-methoxycarbonyl)-L-Threonine
CategoryGlycoamino AcidsThreonine
CAS No.125760-33-0
FormulaC45H54N2O21
Molecular Weight958.91
AvailabilityYes
Availability in BulkYes
Purity>95% (HPLC)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1 glycan) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy.
CommentsN-Acetyl-D-Galactosamine; O-Link; Disaccharide; Threonine; Blocked; Amino Acid; Ac
ReferencesF.J. Irazoqui et al., Immunology and Cell Biology 2005, 83, 405–415
Datasheet(s)GA131010_COA.pdf (84.8 KB)
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