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Tn Antigen (Threonine, Fmoc, Peracetylated)

Tn Antigen (Threonine, Fmoc, Peracetylated) molecular structure

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SKUPack SizeAvailabilityPriceQuantity
GA131000-25MG25mgIn StockUS$325.00
GA131000-100MG100mgIn StockUS$750.00
GA131000-250MG250mgIn StockUS$1,600.00
GA131000-500MG500mgIn StockUS$2,900.00
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Product Details

Name Tn Antigen (Threonine, Fmoc, Peracetylated)
Product No.GA131000
Synonym(s) Fmoc-Thr(α-D-GalNAc(Ac)₃)-OH; Fmoc-Thr[GalNAc(Ac)₃-α-D]-OH; N-α-Fmoc-O-β-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-Threonine
CategoryGlycoamino AcidsThreonine
CAS No.116783-35-8
FormulaC33H38N2O13
Molecular Weight670.66
AvailabilityYes
Availability in BulkYes
Purity>95% (HPLC)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). Tn is a truncated O-glycosylated core determinant with structure: GalNAcα-O-Ser/Thr. In normal Mamalian cells, the Tn determinant is masked by larger glycan residues. Once unmasked, Tn serves as an important recognition element, mediating several cell-cell interactions. As such, Tn is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered Tn a prime target for cancer immunotherapy.
CommentsN-Acetyl-D-Galactosamine; O-Link; Monosaccharide; Threonine; Blocked; Amino Acid; Ac
ReferencesT. Ju, V.I. Otto and R.D. Cummings Angew. Chem. Int. Ed. 2011, 50, 1770 – 1794
Datasheet(s)GA131000_COA.pdf (84.002 KB)
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