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Core 3 O-Glycan (Serine, Fmoc, Peracetylated)

Core 3 O-Glycan (Serine, Fmoc, Peracetylated) molecular structure

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SKUPack SizeAvailabilityPriceQuantity
GA121025-25MG25mgIn StockUS$875.00
GA121025-50MG50mgIn StockUS$1,300.00
GA121025-100MG100mgIn StockUS$1,800.00
GA121025-250MG250mgIn StockUS$3,500.00
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Product Details

Name Core 3 O-Glycan (Serine, Fmoc, Peracetylated)
Product No.GA121025
Synonym(s) Fmoc-Ser(β-GlcNAc(Ac)₃-(1-3)-α-GalNAc(Ac)₂)-OH; Fmoc-Ser(β-GlcNAc-(1-3)-α-GalNAc)-OH, Peracetate
CategoryGlycoamino AcidsSerine
FormulaC44H53N3O20
Molecular Weight943.9
AvailabilityYes
Availability in BulkYes
Purity>95% (HPLC)
DescriptionCore Glycan: Core 3 glycan is one of 4 core structures of O-GalNAc glycans of mucins. Core 3 β1,3-N-acetylglucosaminyltransferase (C3GnT) controls the biosynthesis of core 3 O-glycans and is expressed mainly in the intestine and salivary glands. Core 3 disaccharide can be further extended to form larger glycans. Reduced core3 synthase activity has been detected in malignant tumor cells and it has been reported that increased core3 O-glycan structure negatively regulates tumorigenesis by regulating the function of α2β1 integrin in prostate cancer.
CommentsN-Acetyl-D-Galactosamine; O-Link; Disaccharide; Serine; Blocked; Amino Acid; Ac
ReferencesLee S. H., et al., J. Biol. Chem. 2009, 284, 17157–17169.
Datasheet(s)GA121025_COA.pdf (82.664 KB)
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