NEW!!! Many of our products can now be purchased online! Please browse the product pages for more information.
For custom quotations/inquiries, contact us through the online form or by emailing info@sussex-research.com. Thank you for your patience as we continue to update our website!

STF Antigen (Serine, Fmoc, Bn Ester, Peracetylated)

STF Antigen (Serine, Fmoc, Bn Ester, Peracetylated) molecular structure

Purchase

SKUPack SizeAvailabilityPriceQuantity
GA121020-25MG25mgBackorderedInquire
GA121020-50MG50mgBackorderedInquire
GA121020-100MG100mgBackorderedInquire
GA121020-250MG250mgBackorderedInquire

Please note, this product has a special shipping requirement that will apply an additional fee in your cart: Dry Ice

Inquire

Product Details

Name STF Antigen (Serine, Fmoc, Bn Ester, Peracetylated)
Product No.GA121020
Synonym(s) ST Antigen (Serine); Fmoc-Ser(α-Neu5Ac(Ac)₄-(2-3)-β-Gal(Ac)₃-(1-3)-α-GalNAc(Ac)₂)-OH; Fmoc-Ser(α-Neu5Ac-(2-3)-β-Gal-(1-3)-α-GalNAc)-OH, Peracetate
CategoryGlycoamino AcidsSerine
FormulaC62H77N3O32
Molecular Weight1376.28
AvailabilityNo - Please inquire for availability information
Availability in BulkYes
Purity>90% (HPLC)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). STF-antigen (also ST) is a sialylated form of the truncated O-glycosylated core determinant TF (also T) with structure: Neu5Acα2-3Galβ1-3GalNAcα-O-Ser/Thr. STF results from an early sialylation of the TF antigen due to overexpression of the enzyme α2,3sialylT and/or disruption of further glycan elongation processes. STF is negligibly expressed in healthy tissues but overexpressed in human carcinomas . As such, STF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered STF a prime target for cancer immunotherapy.
CommentsN-Acetyl-D-Galactosamine; O-Link; Trisaccharide; Serine; Blocked; Amino Acid; Ac, Me
‹ Back to Catalogue