NEW!!! Many of our products can now be purchased online! Please browse the product pages for more information.
For custom quotations/inquiries, contact us through the online form or by emailing info@sussex-research.com. Thank you for your patience as we continue to update our website!

STn Antigen (Serine, Fmoc, Benzyl Ester, Peracetylated)

STn Antigen (Serine, Fmoc, Benzyl Ester, Peracetylated) molecular structure

Purchase

SKUPack SizeAvailabilityPriceQuantity
GA121015-25MG25mgIn StockUS$950.00
GA121015-50MG50mgIn StockUS$1,500.00
GA121015-100MG100mgIn StockUS$2,500.00
GA121015-250MG250mgIn StockUS$5,000.00

Please note, this product has a special shipping requirement that will apply an additional fee in your cart: Dry Ice

Inquire

Product Details

Name STn Antigen (Serine, Fmoc, Benzyl Ester, Peracetylated)
Product No.GA121015
Synonym(s) Fmoc-Ser(STn)-OH (Bn, peracetate, free acid); Fmoc-Ser(α-Neu5Ac(Ac)₄-(2-6)-α-GalNAc(Ac)₂)-OH, Benzyl Ester; Fmoc-Ser(α-Neu5Ac-(2-6)-α-GalNAc)-OH, Peracetate, Benzyl Ester
CategoryGlycoamino AcidsSerine
CAS No.914456-67-0
FormulaC56H65N3O24
Molecular Weight1164.12
AvailabilityYes
Availability in BulkYes
Purity>95% (HPLC)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). STn is a sialylated form of the truncated O-glycosylated core determinant Tn with structure: Neu5Acα2-6GalNAcα-O-Ser/Thr. STn results from an early sialylation of the Tn antigen due to overexpression of the enzyme STn synthase (ST6GalNAc-I) and/or disruption of further glycan elongation processes. STn is negligibly expressed in healthy tissues but overexpressed in >80% of human carcinomas. As such, STn is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered STn a prime target for cancer immunotherapy.
CommentsN-Acetyl-D-Galactosamine; O-Link; Disaccharide; Serine; Blocked; Amino Acid; Ac, Bz
ReferencesJ. Munkley, Int J Mol Sci. 2016, 17, 275; M. Sletmoen, et al. Glycobiology 2018, 28, 437–445
Datasheet(s)GA121015_COA.pdf (83.541 KB)
‹ Back to Catalogue