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Tn Antigen (Serine, Fmoc, Peracetylated)

Tn Antigen (Serine, Fmoc, Peracetylated) molecular structure

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Product Details

Name Tn Antigen (Serine, Fmoc, Peracetylated)
Product No.GA121000
Synonym(s) Fmoc-Ser(α-D-GalNAc(Ac)₃)-OH; Fmoc-Ser[GalNAc(Ac)₃-α-D]-OH; Fmoc-Ser(α-D-GalNAc)-OH, Peracetate; N-α-Fmoc-O-β-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-Serine; N-(9-fluorenylmethoxycarbonyl)-O-(3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-α-D-galactopyranosyl)-L-Serine
CategoryGlycoamino AcidsSerine
CAS No.120173-57-1
FormulaC32H36N2O13
Molecular Weight656.63
AvailabilityYes
Availability in BulkYes
Purity>95% (HPLC)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). Tn is a truncated O-glycosylated core determinant with structure: GalNAcα-O-Ser/Thr. In normal Mamalian cells, the Tn determinant is masked by larger glycan residues. Once unmasked, Tn serves as an important recognition element, mediating several cell-cell interactions. As such, Tn is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered Tn a prime target for cancer immunotherapy.
CommentsN-Acetyl-D-Galactosamine; O-Link; Monosaccharide; Serine; Blocked; Amino Acid; Ac
ReferencesT. Ju, V.I. Otto and R.D. Cummings Angew. Chem. Int. Ed. 2011, 50, 1770 – 1791
Datasheet(s)GA121000_COA.pdf (85.359 KB)
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