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Thiamet-G Triacetate

Thiamet-G Triacetate molecular structure


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Product Details

Name Thiamet-G Triacetate
Product No.IN201000
Synonym(s) (3aR,6S,7R,7aS)-2-(Ethylamino)-5,6,7,7a-tetrahydro-5-(acetoxymethyl)pyrano[3,2-d]thiazole-6,7-diacetate
CategoryGlycobiology Tools, Click Chemistry & ProbesInhibitors
Molecular Weight374.41
AvailabilityNo - Please inquire for availability information
Availability in BulkYes
Purity>95% (HPLC)
DescriptionThiamet-G is a highly selective inhibitor of O-GlcNAc-specific hexosaminidase (O-GlcNAcase) in humans; Thiamet-G may find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological hyperphosphorylation of tau in Alzheimer’s disease
CommentsN-Acetylglucosamine; GlcNAc; O-GlcNAcase Inhibitor; Monosaccharide; Thiazoline
ReferencesS.A. Yuzwa et al., Nature Chemical Biology 2008, 4, 483-490.
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