| Name |
Thiamet-G
|
|---|
| Product No. | IN200000 |
|---|
| Synonym(s) |
(3aR,6S,7R,7aS)-2-(Ethylamino)-5,6,7,7a-tetrahydro-5-(hydroxymethyl)pyrano[3,2-d]thiazole-6,7-diol
|
|---|
| Category | Glycobiology Tools, Click Chemistry & ProbesInhibitors |
|---|
| CAS No. | 1009816-48-1 |
|---|
| Formula | C9H16N2O4S
|
|---|
| Molecular Weight | 248.3 |
|---|
| Availability | Yes |
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| Availability in Bulk | Yes |
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| Purity | >95% (HPLC) |
|---|
| Description | Thiamet-G is a highly selective inhibitor of O-GlcNAc-specific hexosaminidase (O-GlcNAcase) in humans; Thiamet-G may find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological hyperphosphorylation of tau in Alzheimer’s disease |
|---|
| Comments | N-Acetylglucosamine; GlcNAc; O-GlcNAcase Inhibitor; Monosaccharide; Thiazoline |
|---|
| References | S.A. Yuzwa et al., Nature Chemical Biology 2008, 4, 483-490. |
|---|
