| Name |
RPB1 CTD: YSPTS(Tn)PSK-NH₂, where Tn = α-D-GalNAc
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| Product No. | GP100095 |
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| Synonym(s) |
DNA-directed RNA polymerase II subunit RPB1 is an enzyme containing a carboxy terminal domain (CTD) composed of up to 52 heptapeptide repeats (YSPTSPS) that are essential for polymerase activity.
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| Category | GlycopeptidesO-Linked |
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| Formula | C46H73N11O18 |
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| Molecular Weight | 1068.1 |
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| Availability | Yes |
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| Availability in Bulk | Yes |
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| Purity | >90% |
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| Description | DNA-directed RNA polymerase II (Pol II) subunit RPB1 contains a Carboxy Terminal Domain (CTD) composed of up to 52 heptapeptide repeats (YSPTSPS) that are essential for polymerase activity. The CTD Nonconsensus Repeat, Tyr-Ser-Pro-Thr-Ser-Pro-Ser, is heavily modified by phosphorylation, glycosylation and proline isomerization. The CTD acts as a tether to bring into close proximity the machinery necessary to synthesize and process Pol II transcripts. |
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| Comments | N-Acetyl-D-Galactosamine; O-Linked; Mono-Glycosylated; L-Serine; C-Terminus-Amide; GP121010 |
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| References | Corden, J.L., Chem Rev. 2013; 113: 8423–8455. |
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