RPB1 CTD: YSPTS(Tn)PSK-NH₂, where Tn = α-D-GalNAc

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GP100095-0.5MG0.5mgIn StockUS$375.00
GP100095-1MG1mgIn StockUS$575.00
GP100095-2MG2mgIn StockUS$975.00
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Name RPB1 CTD: YSPTS(Tn)PSK-NH₂, where Tn = α-D-GalNAc
Product No.GP100095
Synonym(s) DNA-directed RNA polymerase II (Pol II) subunit RPB1 contains a Carboxy Terminal Domain (CTD) composed of up to 52 heptapeptide repeats (YSPTSPS) that are essential for polymerase activity. The CTD Nonconsensus Repeat, Tyr-Ser-Pro-Thr-Ser-Pro-Ser, is heavily modified by phosphorylation, glycosylation and proline isomerization. The CTD acts as a tether to bring into close proximity the machinery necessary to synthesize and process Pol II transcripts.
CategoryGlycopeptidesO-Linked
FormulaC46H73N11O18
Molecular Weight1068.1
AvailabilityYes
Availability in BulkYes
Purity>90%
DescriptionDNA-directed RNA polymerase II (Pol II) subunit RPB1 contains a Carboxy Terminal Domain (CTD) composed of up to 52 heptapeptide repeats (YSPTSPS) that are essential for polymerase activity. The CTD Nonconsensus Repeat, Tyr-Ser-Pro-Thr-Ser-Pro-Ser, is heavily modified by phosphorylation, glycosylation and proline isomerization. The CTD acts as a tether to bring into close proximity the machinery necessary to synthesize and process Pol II transcripts.
CommentsN-Acetyl-D-Galactosamine; O-Linked; Mono-Glycosylated; L-Serine; C-Terminus-Amide; GP121010
ReferencesCorden, J.L., Chem Rev. 2013; 113: 8423–8455.
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