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IgA1 Hinge Peptide: HYTNPSQDVTVPCPVPSTPPTPS(α-GalNAc)PSTPPTPSPSCCHPR-NH₂

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SKUPack SizeAvailabilityPriceQuantity
GP100050-0.5MG0.5mgIn StockUS$375.00
GP100050-1MG1mgIn StockUS$575.00
GP100050-2MG2mgIn StockUS$975.00
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Product Details

Name IgA1 Hinge Peptide: HYTNPSQDVTVPCPVPSTPPTPS(α-GalNAc)PSTPPTPSPSCCHPR-NH₂
Product No.GP100050
Synonym(s) HP(208-245)-Tn(230)
CategoryGlycopeptidesO-Linked
FormulaC179H275N49O60S3
Molecular Weight4169.59
AvailabilityYes
Availability in BulkYes
Purity>98%
DescriptionImmunoglobulin A (IgA1) tryptic peptide: Hinge Region glycopeptide fragment Hys208-Arg245 with GalNAc (Tn) glycosylation at Ser230. Immunoglobulin A (IgA) is the most abundantly produced antibody with an important role in mucosal immunity. Occurring in two structurally and functionally distinctive subclasses (IgA1 and IgA2), aberrant O-glycosylation in the hinge region of IgA1 plays a key role in the pathogenesis of IgA nephropathy (IgAN).
CommentsN-Acetyl-D-Galactosamine; O-Linked; Mono-Glycosylated; L-Serine; C-Terminus-Amide
ReferencesV. Franc et al., J Proteomics 2013, 92, 299–312.
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