IgA1 Hinge Peptide: HYTNPSQDVTVPCPVPSTPPTPS(α-GalNAc)PSTPPTPSPSCCHPR-NH₂
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Product Details
Name | IgA1 Hinge Peptide: HYTNPSQDVTVPCPVPSTPPTPS(α-GalNAc)PSTPPTPSPSCCHPR-NH₂ |
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Product No. | GP100050 |
Synonym(s) | HP(208-245)-Tn(230) |
Category | GlycopeptidesO-Linked |
Formula | C179H275N49O60S3 |
Molecular Weight | 4169.59 |
Availability | Yes |
Availability in Bulk | Yes |
Purity | >98% |
Description | Immunoglobulin A (IgA1) tryptic peptide: Hinge Region glycopeptide fragment Hys208-Arg245 with GalNAc (Tn) glycosylation at Ser230. Immunoglobulin A (IgA) is the most abundantly produced antibody with an important role in mucosal immunity. Occurring in two structurally and functionally distinctive subclasses (IgA1 and IgA2), aberrant O-glycosylation in the hinge region of IgA1 plays a key role in the pathogenesis of IgA nephropathy (IgAN). |
Comments | N-Acetyl-D-Galactosamine; O-Linked; Mono-Glycosylated; L-Serine; C-Terminus-Amide |
References | V. Franc et al., J Proteomics 2013, 92, 299–312. |