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N-Acetyl-D-glucosamine: Fmoc-Thr(GlcNAc(Ac)₃-β-D)-OH

N-Acetyl-D-glucosamine: Fmoc-Thr(GlcNAc(Ac)₃-β-D)-OH molecular structure


SKUPack SizeAvailabilityPriceQuantity
GA231000-50MG50mgIn StockUS$350.00
GA231000-100MG100mgIn StockUS$600.00
GA231000-250MG250mgIn StockUS$1,100.00
GA231000-500MG500mgIn StockUS$1,950.00

Product Details

Name N-Acetyl-D-glucosamine: Fmoc-Thr(GlcNAc(Ac)₃-β-D)-OH
Product No.GA231000
Synonym(s) O-GlcNAc / Threonine; Fmoc-L-Thr(GlcNAc(Ac)₃-β-D)-OH; Fmoc-Thr(β-D-GlcNAc)-OH (Peracetate); Fmoc-Thr(beta-D-GlcNAc)-OH (Peracetate); N-α-Fmoc-O-β-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-L-threonine; N-α-Fmoc-O-β-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosyl)-L-threonine
CategoryGlycoamino AcidsThreonine
CAS No.160168-40-1
Molecular Weight670.66
Availability in BulkYes
Purity>95% (HPLC)
DescriptionO-GlcNAc on proteins plays fundamental roles as a cellular nutrient and stress sensor and thus central in the etiologies of chronic diseases of aging, including diabetes, cancer and neurodegenerative disease. In dynamic protein glycosylation, reversible β-O-GlcNAc modification of nuclear and cytoplasmic proteins at serine and threonine controls diverse aspects of cell physiology and is conceptually analogous to phosphorylation.
CommentsN-Acetyl-D-Glucosamine; GlcNAc; O-Link; Monosaccharide; Threonine; Blocked; Amino Acid; Ac
ReferencesHart G.W. et al., Annu. Rev. Biochem., 2011, 80, 825-858; Hart G.W., J. Biol. Chem. 2019, 294, 2211-2231.
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