| Name |
Fmoc-Thr(β-D-GlcNAc(Ac)₃)-OH
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| Product No. | GA231000 |
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| Synonym(s) |
O-GlcNAc / Threonine; Fmoc-Thr(β-D-GlcNAc)-OH, Peracetate; Fmoc-Thr(GlcNAc(Ac)₃-β-D)-OH; N-α-Fmoc-O-β-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosyl)-L-threonine
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| Category | Glycoamino AcidsThreonine |
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| CAS No. | 160168-40-1 |
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| Formula | C33H38N2O13 |
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| Molecular Weight | 670.66 |
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| Availability | Yes |
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| Availability in Bulk | Yes |
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| Purity | >95% (HPLC) |
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| Description | O-GlcNAc on proteins plays fundamental roles as a cellular nutrient and stress sensor and thus central in the etiologies of chronic diseases of aging, including diabetes, cancer and neurodegenerative disease. In dynamic protein glycosylation, reversible β-O-GlcNAc modification of nuclear and cytoplasmic proteins at serine and threonine controls diverse aspects of cell physiology and is conceptually analogous to phosphorylation. |
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| Comments | N-Acetyl-D-Glucosamine; GlcNAc; O-Link; Monosaccharide; Threonine; Blocked; Amino Acid; Ac |
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| References | Hart G.W. et al., Annu. Rev. Biochem., 2011, 80, 825-858;
Hart G.W., J. Biol. Chem. 2019, 294, 2211-2231. |
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