| Name |
TF Antigen (Threonine, NHAc, Methyl Ester)
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| Product No. | GA134000 |
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| Synonym(s) |
Ac-Thr(α-Galβ(1-3) GalNAc)-OCH₃; T Antigen (Threonine, blocked amino acid)
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| Category | Glycoamino AcidsThreonine |
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| Formula | C21H36N2O14 |
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| Molecular Weight | 540.52 |
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| Availability | Yes |
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| Availability in Bulk | Yes |
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| Purity | >95% (NMR) |
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| Description | Tumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy. |
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| Comments | N-Acetyl-D-Galactosamine; O-Link; Disaccharide; Threonine; Blocked; Amino Acid; Ac |
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| Datasheet(s) | GA134000_COA.pdf (85.918 KB)
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