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Core 3 O-Glycan: Fmoc-Thr(GlcNAcβ(1-3)GalNAc)-OH (Peracetate)

Core 3 O-Glycan: Fmoc-Thr(GlcNAcβ(1-3)GalNAc)-OH (Peracetate) molecular structure


SKUPack SizeAvailabilityPriceQuantity
GA131025-25MG25mgIn StockUS$940.00
GA131025-50MG50mgIn StockUS$1,400.00
GA131025-100MG100mgIn StockUS$1,950.00
GA131025-250MG250mgIn StockUS$3,500.00

Product Details

Name Core 3 O-Glycan: Fmoc-Thr(GlcNAcβ(1-3)GalNAc)-OH (Peracetate)
Product No.GA131025
Synonym(s) Core 3 O-Glycan on Threonine; Fmoc-Thr(β-D-GlcNAc(Ac)₃-(1-3)-α-D-GalNAc(Ac)₂)-OH
CategoryGlycoamino AcidsThreonine
Molecular Weight957.93
Availability in BulkYes
Purity>95% (HPLC)
DescriptionCore Glycan: Core 3 glycan is one of 4 core structures of O-GalNAc glycans of mucins. Core 3 β1,3-N-acetylglucosaminyltransferase (C3GnT) controls the biosynthesis of core 3 O-glycans and is expressed mainly in the intestine and salivary glands. Core 3 disaccharide can be further extended to form larger glycans. Reduced core3 synthase activity has been detected in malignant tumor cells and it has been reported that increased core3 O-glycan structure negatively regulates tumorigenesis by regulating the function of α2β1 integrin in prostate cancer.
CommentsN-Acetyl-D-Galactosamine; O-Link; Disaccharide; Threonine; Blocked; Amino Acid; Ac
ReferencesLee S. H., et al., J. Biol. Chem. 2009, 284, 17157–17169.
Datasheet(s)GA131025_COA.pdf (54.337 KB)
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