STf Antigen: Fmoc-Thr(Neu5Acα(2-3)Galβ(1-3)GalNAc)-OH (Peracetate, Methyl Ester)
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Product Details
| Name | STf Antigen: Fmoc-Thr(Neu5Acα(2-3)Galβ(1-3)GalNAc)-OH (Peracetate, Methyl Ester) |
|---|---|
| Product No. | GA131020 |
| Synonym(s) | STf Epitope (Threonine); STf Antigen (Threonine); ST Antigen; Sialyl-T Antigen; Fmoc-Thr(α-L-Neu5Ac(Ac)₄-(2-3)-β-D-Gal(Ac)₃-(1-3)-α-D-GalNAc(Ac)₂)-OH |
| Category | Glycoamino AcidsThreonine |
| CAS No. | 125760-33-0 |
| Formula | C63H79N3O32 |
| Molecular Weight | 1390.3 |
| Availability | Yes |
| Availability in Bulk | Yes |
| Purity | >90% (HPLC) |
| Description | Tumor-Associated Carbohydrate Antigen (TACA). STF-antigen (also ST) is a sialylated form of the truncated O-glycosylated core determinant TF (also T) with structure: Neu5Acα2-3Galβ1-3GalNAcα-O-Ser/Thr. STF results from an early sialylation of the TF antigen due to overexpression of the enzyme α2,3sialylT and/or disruption of further glycan elongation processes. STF is negligibly expressed in healthy tissues but overexpressed in human carcinomas . As such, STF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered STF a prime target for cancer immunotherapy. |
| Comments | N-Acetyl-D-Galactosamine; O-Link; Trisaccharide; Threonine; Blocked; Amino Acid; Ac; Me |
| Datasheet(s) | GA131020_COA.pdf (89.684 KB) |