| Name |
STF Antigen (Threonine, Fmoc, Methyl Ester, Peracetylated)
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| Product No. | GA131020 |
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| Synonym(s) |
Fmoc-Thr(Neu5Acα2-3Galβ1-3GalNAc)-OH (peracetylated, methyl ester); ST Antigen (Fmoc-Threonine, Peracetate, Methyl ester); α(2,3)Sialyl TF Antigen (Fmoc-Threonine, Peracetate, Methyl ester); Neu5Acα(2,3)Galβ(1,3)GalNAcα–Thr (Fmoc, Peracetate, Methyl ester); Nα-(Fluoren-9-ylmethoxycarbonyl)-O-[(methyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonate)-(2→3)-2,4,6-tri-O-acetyl-β-D-galactopyranosyl-(1→3)-2-N-acetamido-2-deoxy-4,6-di-O-acetyl-α-D-]-L-threonine
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| Category | Glycoamino AcidsThreonine |
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| CAS No. | 125760-33-0 |
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| Formula | C63H79N3O32 |
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| Molecular Weight | 1390.3 |
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| Availability | Yes |
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| Availability in Bulk | Yes |
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| Purity | >90% (HPLC) |
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| Description | Tumor-Associated Carbohydrate Antigen (TACA). STF-antigen (also ST) is a sialylated form of the truncated O-glycosylated core determinant TF (also T) with structure: Neu5Acα2-3Galβ1-3GalNAcα-O-Ser/Thr. STF results from an early sialylation of the TF antigen due to overexpression of the enzyme α2,3sialylT and/or disruption of further glycan elongation processes. STF is negligibly expressed in healthy tissues but overexpressed in human carcinomas . As such, STF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered STF a prime target for cancer immunotherapy. |
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| Comments | N-Acetyl-D-Galactosamine; O-Link; Trisaccharide; Threonine; Blocked; Amino Acid; Ac; Me |
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| Datasheet(s) | GA131020_COA.pdf (89.684 KB)
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