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STn Antigen: Fmoc-Thr(Neu5Acα(2-6)GalNAc)-OH (Peracetate, Benzyl Ester)

STn Antigen: Fmoc-Thr(Neu5Acα(2-6)GalNAc)-OH (Peracetate, Benzyl Ester) molecular structure

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GA131015-25MG25mgIn StockUS$1,025.00
GA131015-50MG50mgIn StockUS$1,600.00
GA131015-100MG100mgIn StockUS$2,700.00
GA131015-250MG250mgIn StockUS$5,375.00

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Product Details

Name STn Antigen: Fmoc-Thr(Neu5Acα(2-6)GalNAc)-OH (Peracetate, Benzyl Ester)
Product No.GA131015
Synonym(s) STn Epitope (Threonine); STn Antigen (Threonine); Sialyl-Tn Antigen; Fmoc-Thr(α-L-Neu5Ac(Ac)₄-(2-6)-α-D-GalNAc(Ac)₂)-OH, Benzyl Ester
CategoryGlycoamino AcidsThreonine
CAS No.189561-77-1
FormulaC57H67N3O24
Molecular Weight1178.15
AvailabilityYes
Availability in BulkYes
Purity>95% (HPLC)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). STn is a sialylated form of the truncated O-glycosylated core determinant Tn with structure: Neu5Acα2-6GalNAcα-O-Ser/Thr. STn results from an early sialylation of the Tn antigen due to overexpression of the enzyme STn synthase (ST6GalNAc-I) and/or disruption of further glycan elongation processes. STn is negligibly expressed in healthy tissues but overexpressed in >80% of human carcinomas. As such, STn is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered STn a prime target for cancer immunotherapy.
CommentsN-Acetyl-D-Galactosamine; O-Link; Disaccharide; Threonine; Blocked; Amino Acid; Ac; Bn
ReferencesJ. Munkley, Int J Mol Sci. 2016, 17, 275; M. Sletmoen, et al. Glycobiology 2018, 28, 437–442
Datasheet(s)GA131015_COA.pdf (83.488 KB)
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