STn Antigen (Threonine, Fmoc, Benzyl Ester, Peracetylated)

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SKU	Pack Size	Availability	Price
GA131015-25MG	25mg	In Stock	US$1,025.00
GA131015-50MG	50mg	In Stock	US$1,600.00
GA131015-100MG	100mg	In Stock	US$2,700.00
GA131015-250MG	250mg	In Stock	US$5,375.00
Please note, this product has a special shipping requirement that will apply an additional fee in your cart: Dry Ice Inquire

Name	STn Antigen (Threonine, Fmoc, Benzyl Ester, Peracetylated)
Product No.	GA131015
Synonym(s)	Fmoc-Thr(α-Neu5Ac(Ac)₄-(2-6)-α-GalNAc(Ac)₂)-OH; Fmoc-Thr(α-Neu5Ac(2-6)-α-GalNAc)-OH, Peracetate, Benzyl Ester
Category	Glycoamino Acids Threonine
CAS No.	189561-77-1
Formula	C₅₇H₆₇N₃O₂₄
Molecular Weight	1178.15
Availability	Yes
Availability in Bulk	Yes
Purity	>95% (HPLC)
Description	Tumor-Associated Carbohydrate Antigen (TACA). STn is a sialylated form of the truncated O-glycosylated core determinant Tn with structure: Neu5Acα2-6GalNAcα-O-Ser/Thr. STn results from an early sialylation of the Tn antigen due to overexpression of the enzyme STn synthase (ST6GalNAc-I) and/or disruption of further glycan elongation processes. STn is negligibly expressed in healthy tissues but overexpressed in >80% of human carcinomas. As such, STn is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered STn a prime target for cancer immunotherapy.
Comments	N-Acetyl-D-Galactosamine; O-Link; Disaccharide; Threonine; Blocked; Amino Acid; Ac; Bn
References	J. Munkley, Int J Mol Sci. 2016, 17, 275; M. Sletmoen, et al. Glycobiology 2018, 28, 437–442
Datasheet(s)	GA131015_COA.pdf (83.488 KB)