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Tf Antigen: Fmoc-Thr(Galβ(1-3)GalNAc)-OH (Peracetate)

Tf Antigen: Fmoc-Thr(Galβ(1-3)GalNAc)-OH (Peracetate) molecular structure


SKUPack SizeAvailabilityPriceQuantity
GA131010-25MG25mgIn StockUS$750.00
GA131010-100MG100mgIn StockUS$1,985.00
GA131010-250MG250mgIn StockUS$4,000.00
GA131010-500MG500mgIn StockUS$6,450.00

Product Details

Name Tf Antigen: Fmoc-Thr(Galβ(1-3)GalNAc)-OH (Peracetate)
Product No.GA131010
Synonym(s) Tf Epitope (Threonine); T Antigen (Threonine,Fmoc, Peracetylated); Thomsen–Friedenreich Antigen; Core 1 Glycan (Threonine); Fmoc-Thr[β-D-Gal(Ac)₄-(1-3)-α-D-GalNAc(Ac)₂]-OH; O-{2-acetamido-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-4,6-di-O-acetyl-2-deoxy-α-D-galactopyranosyl}-N α-(fluoren-9-yl-methoxycarbonyl)-L-Threonine
CategoryGlycoamino AcidsThreonine
CAS No.125760-33-0
Molecular Weight958.91
Availability in BulkYes
Purity>95% (HPLC)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1 glycan) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy.
CommentsN-Acetyl-D-Galactosamine; O-Link; Disaccharide; Threonine; Blocked; Amino Acid; Ac
ReferencesF.J. Irazoqui et al., Immunology and Cell Biology 2005, 83, 405–415
Datasheet(s)GA131010_COA.pdf (84.8 KB)
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