| Name |
Tn Antigen (Threonine, Fmoc, Peracetylated)
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| Product No. | GA131000 |
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| Synonym(s) |
Fmoc-Thr(α-D-GalNAc(Ac)₃)-OH; Fmoc-Thr[GalNAc(Ac)₃-α-D]-OH; N-α-Fmoc-O-β-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-Threonine
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| Category | Glycoamino AcidsThreonine |
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| CAS No. | 116783-35-8 |
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| Formula | C33H38N2O13 |
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| Molecular Weight | 670.66 |
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| Availability | Yes |
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| Availability in Bulk | Yes |
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| Purity | >95% (HPLC) |
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| Description | Tumor-Associated Carbohydrate Antigen (TACA). Tn is a truncated O-glycosylated core determinant with structure: GalNAcα-O-Ser/Thr. In normal Mamalian cells, the Tn determinant is masked by larger glycan residues. Once unmasked, Tn serves as an important recognition element, mediating several cell-cell interactions. As such, Tn is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered Tn a prime target for cancer immunotherapy. |
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| Comments | N-Acetyl-D-Galactosamine; O-Link; Monosaccharide; Threonine; Blocked; Amino Acid; Ac |
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| References | T. Ju, V.I. Otto and R.D. Cummings Angew. Chem. Int. Ed. 2011, 50, 1770 – 1794 |
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| Datasheet(s) | GA131000_COA.pdf (84.002 KB)
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