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TF Antigen (Threonine standard)

TF Antigen (Threonine standard) molecular structure


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Product Details

Name TF Antigen (Threonine standard)
Product No.GA130010
Synonym(s) H-Thr(Gal β(1-3)GalNAc)-OH; T Antigen (Threonine standard); O-[2-acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-α-D-galactopyranosyl]-L-Threonine
CategoryGlycoamino AcidsThreonine
CAS No.60280-58-2
Molecular Weight484.46
AvailabilityNo - Please inquire for availability information
Availability in BulkYes
Purity>95% (NMR)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy.
CommentsN-Acetyl-D-Galactosamine; O-Link; Disaccharide; Threonine; Free OH; Amino Acid;
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