| Name |
TF Antigen (Threonine standard)
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| Product No. | GA130010 |
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| Synonym(s) |
H-Thr(Gal β(1-3)GalNAc)-OH; T Antigen (Threonine standard); O-[2-acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-α-D-galactopyranosyl]-L-Threonine
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| Category | Glycoamino AcidsThreonine |
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| CAS No. | 60280-58-2 |
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| Formula | C18H32N2O13 |
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| Molecular Weight | 484.46 |
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| Availability | No - Please inquire for availability information |
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| Availability in Bulk | Yes |
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| Purity | >95% (NMR) |
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| Description | Tumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy. |
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| Comments | N-Acetyl-D-Galactosamine; O-Link; Disaccharide; Threonine; Free OH; Amino Acid; |
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