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Tn Antigen: H-Thr(α-D-GalNAc)-OH

Tn Antigen: H-Thr(α-D-GalNAc)-OH molecular structure


SKUPack SizeAvailabilityPriceQuantity
GA130000-1MG1mgIn StockUS$225.00
GA130000-2MG2mgIn StockUS$350.00
GA130000-5MG5mgIn StockUS$500.00
GA130000-10MG10mgIn StockUS$750.00

Product Details

Name Tn Antigen: H-Thr(α-D-GalNAc)-OH
Product No.GA130000
Synonym(s) Tn Epitope (Threonine); GalNAc-α-1-O-Threonine; GalNAc-Threonine; O-(2-Acetamido-2-deoxy-α-D-galactopyranosyl)-L-threonine
CategoryGlycoamino AcidsThreonine
Molecular Weight322.31
Availability in BulkYes
Purity>95% (NMR)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). Tn is a truncated O-glycosylated core determinant with structure: GalNAcα-O-Ser/Thr. In normal Mamalian cells, the Tn determinant is masked by larger glycan residues. Once unmasked, Tn serves as an important recognition element, mediating several cell-cell interactions. As such, Tn is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered Tn a prime target for cancer immunotherapy.
CommentsN-Acetyl-D-Galactosamine; O-Link; Monosaccharide; Threonine; Free OH; Amino Acid;
Datasheet(s)GA130000_COA.pdf (81.973 KB)
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