| Name |
TF Antigen (Serine, NHAc, Methyl Ester)
|
|---|
| Product No. | GA124000 |
|---|
| Synonym(s) |
Ac-Ser(α-Galβ(1-3)GalNAc)-OCH₃; T Antigen (Serine, blocked amino acid)
|
|---|
| Category | Glycoamino AcidsSerine |
|---|
| Formula | C2H34N2O14 |
|---|
| Molecular Weight | 526.49 |
|---|
| Availability | Yes |
|---|
| Availability in Bulk | Yes |
|---|
| Purity | >95% (NMR) |
|---|
| Description | Tumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy. |
|---|
| Comments | N-Acetyl-D-Galactosamine; O-Link; Disaccharide; Serine; Blocked; Amino Acid; Ac; Me |
|---|
| Datasheet(s) | GA124000_COA.pdf (83.077 KB)
|
|---|
