Name |
Core 3 O-Glycan (Serine, Fmoc, Peracetylated)
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Product No. | GA121025 |
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Synonym(s) |
Fmoc-Ser(β-GlcNAc(Ac)₃-(1-3)-α-GalNAc(Ac)₂)-OH; Fmoc-Ser(β-GlcNAc-(1-3)-α-GalNAc)-OH, Peracetate
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Category | Glycoamino AcidsSerine |
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Formula | C44H53N3O20 |
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Molecular Weight | 943.9 |
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Availability | Yes |
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Availability in Bulk | Yes |
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Purity | >95% (HPLC) |
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Description | Core Glycan: Core 3 glycan is one of 4 core structures of O-GalNAc glycans of mucins. Core 3 β1,3-N-acetylglucosaminyltransferase (C3GnT) controls the biosynthesis of core 3 O-glycans and is expressed mainly in the intestine and salivary glands. Core 3 disaccharide can be further extended to form larger glycans. Reduced core3 synthase activity has been detected in malignant tumor cells and it has been reported that increased core3 O-glycan structure negatively regulates tumorigenesis by regulating the function of α2β1 integrin in prostate cancer. |
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Comments | N-Acetyl-D-Galactosamine; O-Link; Disaccharide; Serine; Blocked; Amino Acid; Ac |
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References | Lee S. H., et al., J. Biol. Chem. 2009, 284, 17157–17169. |
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Datasheet(s) | GA121025_COA.pdf (82.664 KB)
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