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STF Antigen (Serine, Fmoc, Bn Ester, Peracetylated)

STF Antigen (Serine, Fmoc, Bn Ester, Peracetylated) molecular structure


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Product Details

Name STF Antigen (Serine, Fmoc, Bn Ester, Peracetylated)
Product No.GA121020
Synonym(s) ST Antigen (Serine); Fmoc-Ser(α-Neu5Ac(Ac)₄-(2-3)-β-Gal(Ac)₃-(1-3)-α-GalNAc(Ac)₂)-OH; Fmoc-Ser(α-Neu5Ac-(2-3)-β-Gal-(1-3)-α-GalNAc)-OH, Peracetate
CategoryGlycoamino AcidsSerine
Molecular Weight1376.28
AvailabilityNo - Please inquire for availability information
Availability in BulkYes
Purity>90% (HPLC)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). STF-antigen (also ST) is a sialylated form of the truncated O-glycosylated core determinant TF (also T) with structure: Neu5Acα2-3Galβ1-3GalNAcα-O-Ser/Thr. STF results from an early sialylation of the TF antigen due to overexpression of the enzyme α2,3sialylT and/or disruption of further glycan elongation processes. STF is negligibly expressed in healthy tissues but overexpressed in human carcinomas . As such, STF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered STF a prime target for cancer immunotherapy.
CommentsN-Acetyl-D-Galactosamine; O-Link; Trisaccharide; Serine; Blocked; Amino Acid; Ac, Me
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