| Name |
STF Antigen (Serine, Fmoc, Bn Ester, Peracetylated)
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| Product No. | GA121020 |
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| Synonym(s) |
ST Antigen (Serine); Fmoc-Ser(α-Neu5Ac(Ac)₄-(2-3)-β-Gal(Ac)₃-(1-3)-α-GalNAc(Ac)₂)-OH; Fmoc-Ser(α-Neu5Ac-(2-3)-β-Gal-(1-3)-α-GalNAc)-OH, Peracetate
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| Category | Glycoamino AcidsSerine |
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| Formula | C62H77N3O32 |
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| Molecular Weight | 1376.28 |
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| Availability | No - Please inquire for availability information |
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| Availability in Bulk | Yes |
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| Purity | >90% (HPLC) |
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| Description | Tumor-Associated Carbohydrate Antigen (TACA). STF-antigen (also ST) is a sialylated form of the truncated O-glycosylated core determinant TF (also T) with structure: Neu5Acα2-3Galβ1-3GalNAcα-O-Ser/Thr. STF results from an early sialylation of the TF antigen due to overexpression of the enzyme α2,3sialylT and/or disruption of further glycan elongation processes. STF is negligibly expressed in healthy tissues but overexpressed in human carcinomas . As such, STF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered STF a prime target for cancer immunotherapy. |
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| Comments | N-Acetyl-D-Galactosamine; O-Link; Trisaccharide; Serine; Blocked; Amino Acid; Ac, Me |
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