| Name |
TF Antigen (Serine, Fmoc, Peracetylated)
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| Product No. | GA121010 |
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| Synonym(s) |
T Antigen (Serine); Core 1 Glycan (Serine); Fmoc-Ser(β-Gal(Ac)₄-(1-3)-α-GalNAc(Ac)₂)-OH; Fmoc-Ser(Gal β(1-3)GalNAc)-OH, Peracetate; O-{2-N-acetyl-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-4,6-di-O-acetyl-2-deoxy-α-D-galactopyranosyl}-N α-(fluoren-9-yl-methoxycarbonyl)-L-Serine
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| Category | Glycoamino AcidsSerine |
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| CAS No. | 125760-30-7 |
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| Formula | C44H52N2O21 |
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| Molecular Weight | 944.88 |
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| Availability | Yes |
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| Availability in Bulk | Yes |
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| Purity | >95% (HPLC) |
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| Description | Tumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy. |
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| Comments | N-Acetyl-D-Galactosamine; O-Link; Disaccharide; Serine; Blocked; Amino Acid; Ac |
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| References | F.J. Irazoqui et al., Immunology and Cell Biology 2005, 83, 405–415 |
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| Datasheet(s) | GA121010_COA.pdf (84.147 KB)
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